Conference Day 2
8:55 am Chair’s Opening Remark
Applying Digital Pathology & Advanced Image Analysis to De-risk the Path From Preclinical Studies to Late-Stage Trials Through Enhanced Understanding of Efficacy
9:00 am Discovering Novel Biomarkers for Digital Analysis
Synopsis
- Identifying the type of biomarker required for quantitative fibrotic measurements
- Considering methods to compare basal levels after the biomarker has been picked up
9:30 am Factoring the Slow Disease Progression by Developing Realistic Study Designs for Fibrosis
Synopsis
- Conducting early biomarker studies and addressing how predictive they are for late stage
- Exploring innovative suggestions for faster studies in fibrosis with a biomarker that has shown a certain level of predictability for a disease
10:00 am Morning Break & Networking
11:00 am Utilizing Digital Pathology to Enhance Quality of Clinical Readouts
Synopsis
- Addressing current state of tissue analysis as a semi-quantitative clinical endpoint with large variability
- Streamlining clinical trial progression by integrating digital pathology more easily
11:30 am Scrutinizing the Translation Between Animal Models & Human Patients for Stronger Endpoint Determination
Synopsis
- Exploring patient-derived models to test novel therapies in a high throughput manner
- Using fibrotic models of multiplexing several readouts for a bigger picture
12:00 pm Panel Discussion: Expanding the Horizons on Innovative Avenues for Standardized Readouts
Synopsis
- Discussing the importance of multiple readouts to enhance efficacy
- Exploring a new format of constructing a panel of pathologists for standardized readouts and image interpretation
1:00 pm Lunch & Networking
Unlocking Disease Pathogenesis: Redefining Early Assessment of Heterogeneous Fibrotic & Inflammatory Disorders Through Leveraging Digital Pathology
2:30 pm Quantifying Changes in NASH Histology Features in Treatments for Children & Adult
Synopsis
- Utilizing image analysis techniques to identify alterations that provide insights for drug discovery and safety applications Evaluating and comparing how different imaging techniques reflect in pathology
- Recognizing the “real world” importance of adapting or including alternatives to liver biopsy in implementation of care
3:00 pm Using Digital Pathology in Pre-Clinical Fibrosis Research & Bridging the Gap With Human Studies
Synopsis
- Selecting previous human studies for early diagnosis to understand which tests are needed
- Deciding on an early or a late long study
- Exploring how to non-invasively solve fibrosis over time
3:30 pm Panel Discussion: Updates on the Current State of Fibrotic Diseases
Synopsis
- Sharing the current understanding of what we know about fibrosis today
- Comparing current state-of-the-art approaches to examining disease progression in the heart, kidney and liver